Accurate diagnosis is essential for management of BAD disease

It is recognised that BAD is a chronic condition requiring long term therapy to achieve a significant improvement in diarrhoea symptoms, and therefore warrants a clear diagnosis; ¹ The results of the SeHCAT scan directly impact the choice of treatment for a person with BAD. ²

SeHCAT results and response to therapy

SeHCAT test has the benefit of being well-tolerated and non-invasive, and there is a clear inverse relationship between 7-day ⁷⁵SeHCAT retention and response to bile acid sequestrants, which remain the first-line therapeutic option. ³
Studies have shown there is a relationship between the severity of the SeHCAT retention and the response to therapy. ⁴
Normal cut off ranges can vary between centres with some preferring to use 10% cut off, as patients with less than 10% bile acid retention are more likely to respond to BAS therapy. ⁵
However, it has been shown that 70% of patients with a retention of less than 15% will also respond to therapy. ⁴

sehcat results and bam therapy — Adapted from Wedlake L et al (2009) ⁶

References:

Lin S, et al. European Journal of Gastroenterology & Hepatology, 2016 pp. 28(2)240-245.
Kumar L et al. Gut 2013 p. 62:A284.
Mottacki N et al. Alliment Pharmacol Ther 2016; 43 (8): 884-98.
Wedlake L et al. Aliment Pharmacol Ther 2009; 30 (7): 707-17.
Smith MJ et al. J R Coll Physicians Lond 2000; 34 (5): 448-51.

JB7828 10-2019